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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Related Experiment Video

Updated: Jul 28, 2025

Competitive Genomic Screens of Barcoded Yeast Libraries
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Microarray patches for managing infections at a global scale.

Qonita Kurnia Anjani1, Akmal Hidayat Bin Sabri2, Aaron J Hutton2

  • 1School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK; Fakultas Farmasi, Universitas Megarezky, Jl. Antang Raya No. 43, Makassar 90234, Indonesia.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|June 1, 2023
PubMed
Summary
This summary is machine-generated.

Microarray patches (MAPs) offer a minimally invasive method for delivering drugs and vaccines to manage global infectious diseases like tuberculosis and COVID-19. This technology also shows promise for biosensing and diagnosis, overcoming key clinical hurdles.

Keywords:
Covid-19Infectious diseaseMRSAMalariaMicroarray patchSkin infectionTuberculosis

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Area of Science:

  • Biomedical Engineering
  • Infectious Diseases
  • Drug Delivery Systems

Background:

  • Microarray patches (MAPs) have evolved from solid designs to advanced bioresponsive systems.
  • There is increasing interest in MAPs for managing infectious diseases due to their minimally invasive nature.
  • MAPs enable self-administration of therapeutics, reducing reliance on healthcare professionals.

Purpose of the Study:

  • To critically analyze the potential of MAPs in managing globally endemic infectious diseases.
  • To review MAPs' utility in treating diseases such as tuberculosis, malaria, and COVID-19.
  • To discuss MAPs' role in preventing emerging infections and their diagnostic capabilities.

Main Methods:

  • Review of existing literature on microarray patch technology for drug delivery.
  • Analysis of MAPs' application in managing specific infectious diseases (tuberculosis, skin infections, malaria, MRSA, COVID-19).
  • Evaluation of MAPs' potential for vaccine delivery, prophylaxis, and biosensing.

Main Results:

  • MAPs offer a painless, minimally invasive approach for therapeutic and vaccine delivery.
  • MAPs can aid in preventing the spread of emerging infectious diseases.
  • MAPs' ability to collect dermal interstitial fluid enables potential use as biosensors for disease diagnosis.

Conclusions:

  • MAPs present a significant potential for managing infectious diseases globally, especially in low- and middle-income countries.
  • The technology offers efficient solutions for both treatment and prevention of infections.
  • Clinical and translational challenges associated with MAP implementation require further investigation.