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Updated: Jul 28, 2025
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
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Measuring exhaled nitric oxide when diagnosing and managing asthma
Payal Sen1, Sumita B Khatri2, Vickram Tejwani3
1Respiratory Institute, Cleveland Clinic, Cleveland, OH senp@ccf.org.
Cleveland Clinic Journal of Medicine
|June 1, 2023
Summary
Measuring exhaled nitric oxide aids asthma diagnosis and management but requires clinical correlation. This biomarker helps predict treatment response and exacerbations, though it lacks standalone sensitivity and specificity.
Area of Science:
- Respiratory Medicine
- Clinical Chemistry
Background:
- Exhaled nitric oxide (FeNO) measurement is explored for asthma assessment.
- Asthma management involves diagnosis, treatment response prediction, and exacerbation risk evaluation.
Purpose of the Study:
- To review the utility of FeNO in diagnosing and managing asthma.
- To provide guidance on the appropriate clinical application of FeNO testing.
Main Methods:
- Review of existing literature on exhaled nitric oxide in asthma.
- Analysis of FeNO's role as an adjunctive diagnostic and monitoring tool.
Main Results:
- FeNO can assist in identifying asthma, predicting response to inhaled corticosteroids, and monitoring therapy.
- FeNO is not sufficiently sensitive or specific for sole diagnostic use; it must complement clinical evaluation.
Conclusions:
- Exhaled nitric oxide measurement is a valuable adjunctive tool in asthma care.
- Clinical signs and symptoms remain crucial alongside FeNO for comprehensive asthma management.
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