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Study protocol: pneumonia and inhaled corticosteroid treatment patterns in chronic obstructive pulmonary disease - a
Allan Klitgaard1,2, Rikke Ibsen3, Ole Hilberg4,2
1Department of Internal Medicine, Lillebaelt Hospital, Vejle, Denmark alksorensen@health.sdu.dk.
BMJ Open
|June 1, 2023
Summary
Inhaled corticosteroids (ICS) reduce COPD exacerbations but increase pneumonia risk. This study identifies patient characteristics linked to this increased pneumonia risk in ICS users.
Area of Science:
- Pulmonary Medicine
- Epidemiology
- Pharmacology
Background:
- Inhaled corticosteroids (ICS) are a cornerstone therapy for chronic obstructive pulmonary disease (COPD), effectively reducing exacerbations.
- However, ICS use is associated with an increased risk of pneumonia, a significant concern for patient safety.
- Identifying specific patient profiles at higher risk for ICS-associated pneumonia is crucial for personalized treatment strategies.
Purpose of the Study:
- To identify patient characteristics associated with an increased risk of pneumonia among individuals treated with inhaled corticosteroids for COPD.
- To inform clinical decision-making regarding ICS prescription and monitoring in COPD patients.
Main Methods:
- A nationwide register-based cohort study utilizing Danish health registers from 2008-2018.
- Individual-level data linkage using unique personal identification numbers.
- Sequence analysis to explore clusters of pneumonia incidence and ICS treatment patterns over a 3-year follow-up period.
Main Results:
- This section is to be populated upon study completion.
Conclusions:
- This section is to be populated upon study completion.
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