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Comut-viz: efficiently creating and browsing comutation plots online.

Qiaonan Duan1, Weiyi Wang2, Feiling Feng3

  • 1Department of Translational Medicine, 3D Medicines Inc., Shanghai, China.

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|June 1, 2023
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Summary

Comut-viz is a new web app that creates mutation comutation plots for genomic studies. It offers interactive customization and handles large datasets, improving upon existing tools.

Keywords:
Comutation plotGenomic analysisMutationVisualizationWeb server

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Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Comutation plots are essential for visualizing mutation landscapes in large-scale genomic studies.
  • Existing tools, including offline packages and online web servers, have limitations in customization and handling large datasets.
  • Offline packages require coding expertise and repetitive adjustments, while web apps often lack flexibility and capacity for extensive data.

Purpose of the Study:

  • To develop an improved tool for creating comutation plots that addresses the limitations of existing methods.
  • To provide a user-friendly, interactive, and customizable web application for genomic data visualization.
  • To enhance the efficiency and accessibility of comutation plot generation for researchers.

Main Methods:

  • Developed Comut-viz, a front-end web application for interactive mutation data visualization.
  • Incorporated frequently adjusted features for plot customization, including colored labels for numeric metadata and adjustable plot dimensions.
  • Enabled handling of large Mutation Annotation Format (MAF) files, exceeding 200,000 rows, without compromising performance.

Main Results:

  • Comut-viz offers interactive filtering and visualization of mutation data, producing downloadable plots.
  • The application features a preloaded color palette and input boxes for adjusting plot width and height.
  • Comut-viz successfully processes large MAF files and ensures user data privacy due to its front-end-only architecture.

Conclusions:

  • Comut-viz is a responsive and extensible web application for generating comutation plots.
  • It provides enhanced customization options for frequently modified plot features and efficiently handles large genomic files.
  • The tool is well-suited for genomic studies involving over a thousand samples, offering a significant improvement over existing solutions.