High-sensitivity troponins and mortality in the general population
John W McEvoy1,2,3, Natalie Daya3, Olive Tang2
1University of Galway School of Medicine and National Institute for Prevention and Cardiovascular Health, Moyola Lane, Newcastle, Galway H91-FF68, Connacht, Ireland.
High-sensitivity cardiac troponin assays show modest correlations. Cardiac troponin I assays provide distinct mortality risk information in the general population, independent of other assays.
Area of Science:
- Cardiology
- Biomarker Research
- Public Health
Background:
- High-sensitivity cardiac troponin T (hs-cTnT) and cardiac troponin I (hs-cTnI) are crucial biomarkers.
- Multiple hs-cTn assays exist, necessitating comparative analysis.
Purpose of the Study:
- To assess correlations between four hs-cTn assays (one T, three I).
- To evaluate the comparative associations of these assays with all-cause and cardiovascular mortality.
Main Methods:
- Analysis of data from 9810 adults without cardiovascular disease in NHANES (1999-2004).
- Measurement of hs-cTnT (Roche) and hs-cTnI (Abbott, Siemens, Ortho).
- Cox regression to determine associations with mortality, with correlation coefficients ranging from 0.53 to 0.77.
Main Results:
- All four hs-cTn assays were independently associated with increased all-cause and cardiovascular mortality.
- hs-cTnT associations remained significant after adjusting for hs-cTnI.
- hs-cTnI assays provided distinct mortality risk information, even after mutual adjustment.
Conclusions:
- Modest correlations exist between hs-cTnT and hs-cTnI assays.
- hs-cTnI assays offer unique prognostic value for mortality in the general population.
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