Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

1.1K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.1K
Data Validation01:15

Data Validation

194
Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
194
Deindividuation00:57

Deindividuation

26.5K
Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.
26.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Low-Dose Naltrexone: What is the Evidence? A Narrative Review.

Advances in therapy·2026
Same author

Mapping the international research on pharmacists' prescribing to initiate medications: a scoping review.

The International journal of pharmacy practice·2026
Same author

Risk of cancer incidence and mortality in patients with chronic pain: A systematic review and meta-analysis.

Cancer metastasis reviews·2026
Same author

Low-Dose Naltrexone: What is the Evidence? A Narrative Review.

Advances in therapy·2026
Same author

Factors Influencing Illicit Drug Substance Abuse and Its Perceived Psychosocial Impact Among Individuals Undergoing Deaddiction Treatment at Male Drug Rehabilitation Centers of Eastern Nepal.

Addiction & health·2026
Same author

Exploring anabasine excretion factor in individuals who use tobacco cigarettes: a preliminary estimate.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2026

Related Experiment Video

Updated: Jul 28, 2025

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
10:05

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

Published on: October 24, 2018

9.5K

Deprescribing Tool for Older PeoPle with Limited-life Expectancy (De-TOPPLE) version 1: Development and validation

Shakti Shrestha1, Arjun Poudel2, Kathryn J Steadman1

  • 1School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.

Basic & Clinical Pharmacology & Toxicology
|June 2, 2023
PubMed
Summary

Clinicians can now use the Deprescribing Tool for Older People with Limited-life Expectancy (De-TOPPLE) to guide medication withdrawal in elderly patients. This validated tool aids decision-making for deprescribing preventive and symptom-control medications.

Keywords:
Delphiconsensusdeprescribingfrailolder adultsterminal illnessvalidation

More Related Videos

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
10:13

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples

Published on: December 2, 2022

2.7K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.1K

Related Experiment Videos

Last Updated: Jul 28, 2025

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
10:05

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

Published on: October 24, 2018

9.5K
Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
10:13

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples

Published on: December 2, 2022

2.7K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.1K

Area of Science:

  • Geriatric Medicine
  • Pharmacotherapy
  • Clinical Decision-Making

Background:

  • Deprescribing medications in older adults with limited life expectancy presents significant clinical challenges.
  • Effective tools are needed to support clinicians in making informed deprescribing decisions.

Purpose of the Study:

  • To develop and validate the Deprescribing Tool for Older People with Limited-life Expectancy (De-TOPPLE).
  • To establish expert consensus on a structured approach for deprescribing in this vulnerable population.

Main Methods:

  • A modified Delphi technique involving geriatric and pharmacotherapy experts was employed over two rounds.
  • Consensus was sought on the tool's approach to risk-benefit analysis, medication categorization, and deprescribing steps.

Main Results:

  • Round 1 achieved consensus on the tool's framework, including risk-benefit evaluation and a stepwise deprescribing process.
  • Round 2 validated the tool's usability, emphasizing time-to-benefit, symptom relief, and shared decision-making for medication cessation or continuation.

Conclusions:

  • The De-TOPPLE version 1 was developed and validated through expert consensus using the Delphi method.
  • Further validation in clinical practice is required after incorporating contextual statements into the tool.