Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mette Petersen1,2, Nina Strandkjær1,2, Jonas Henrik Kristensen1,2

  • 1Akutmodtagelsen, Københavns Universitetshospital - Herlev og Gentofte Hospital.

Ugeskrift for Laeger
|June 2, 2023
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Interference and misleading blood test results].

Ugeskrift for laeger·2026
Same author

Discussion forum response to: High diagnostic yield of family echocardiographic screening of children with bicuspid aortic valve: a critical appraisal and future directions.

European heart journal. Cardiovascular Imaging·2026
Same author

Association of HDL cholesterol, apolipoprotein AI, and E concentrations with foetal growth and placental insufficiency.

Cardiovascular research·2026
Same author

Hyperbaric Oxygen Treatment as a Novel Add-on in Selected Patients with Infective Endocarditis - A Safety and Feasibility Trial.

Infection and drug resistance·2026
Same author

Prosthetic Valve Endocarditis-Insights from the NatIonal Danish Endocarditis stUdieS (NIDUS) Registry.

Diagnostics (Basel, Switzerland)·2026
Same author

Stability of whole blood samples at different temperatures: a systematic review.

Diagnosis (Berlin, Germany)·2026
Same journal

[Mosaicism as a cause of Cowden syndrome].

Ugeskrift for laeger·2026
Same journal

[Thyrotoxic crisis with cardiogenic shock].

Ugeskrift for laeger·2026
Same journal

[Mindfulness-based cognitive therapy in the treatment of depression].

Ugeskrift for laeger·2026
Same journal

[Fitness].

Ugeskrift for laeger·2026
Same journal

[Risk of developing cataract related to fluoroscopy].

Ugeskrift for laeger·2026
Same journal

[Obturator hernia with small bowel ileus presenting as hip pain in an elderly woman].

Ugeskrift for laeger·2026
See all related articles
This summary is machine-generated.

New sensitive cardiac troponin tests increase false positives. Kidney disease and analytical interference are key causes, requiring careful interpretation and repeat testing with different assays when results conflict with clinical signs.

Area of Science:

  • Cardiology
  • Clinical Chemistry
  • Laboratory Medicine

Background:

  • Highly sensitive cardiac troponin assays improve early detection of myocardial infarction but increase the risk of false-positive results.
  • Elevated cardiac troponin levels can stem from various non-cardiac conditions, notably chronic kidney disease.
  • Discrepancies between troponin measurements and clinical presentation necessitate careful evaluation.

Approach:

  • This review synthesizes current understanding of factors contributing to false-positive cardiac troponin measurements.
  • It highlights the importance of considering non-cardiac causes of troponin release.
  • The utility of serial troponin testing with different assays to identify analytical interference is discussed.

Key Points:

  • Increased sensitivity of modern cardiac troponin assays elevates the likelihood of false positives.

Related Experiment Videos

  • Non-cardiac conditions, especially kidney disease, are significant contributors to troponin release.
  • Analytical interference represents a critical, often overlooked, cause of inaccurate troponin levels.
  • Discrepant troponin results warrant consideration of analytical interference and may require repeat testing with an alternative assay.

    • Conclusions:

    • Clinicians must be aware of the potential for false-positive cardiac troponin results due to assay sensitivity.
    • Differential diagnosis should include non-cardiac etiologies and potential analytical interferences.
    • Utilizing serial measurements with different assays is crucial for resolving discrepancies and ensuring accurate diagnosis.