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Recurrence patterns among patients with sinonasal mucosal melanoma: A multi-institutional study
Vivek C Pandrangi1, Jess C Mace1, Arash Abiri2
1Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
International Forum of Allergy & Rhinology
|June 2, 2023
Summary
Sinonasal mucosal melanoma (SNMM) has a high recurrence rate and poor survival. While primary neck treatment did not reduce recurrence, immunotherapy showed a 12-month survival benefit for distant recurrence in SNMM patients.
Area of Science:
- Oncology
- Head and Neck Surgery
- Melanoma Research
Background:
- Sinonasal mucosal melanoma (SNMM) is a rare and aggressive malignancy.
- Understanding recurrence patterns and survival outcomes is crucial for improving patient management.
Purpose of the Study:
- To analyze recurrence patterns in SNMM.
- To evaluate survival rates after recurrence in SNMM patients.
- To assess the impact of primary neck treatment and specific therapies on survival.
Main Methods:
- Multi-institutional retrospective review of 196 SNMM patients (1991-2022).
- Recurrence categorized as local, regional, distant, or multifocal.
- Kaplan-Meier and Cox-regression analyses for disease-free survival (DFS), overall survival (OS), and post-recurrence survival (PRS).
Main Results:
- High recurrence rate (74.5%) observed.
- Isolated distant recurrence was most frequent (42.8%).
- Primary neck treatment did not significantly impact DFS. Immunotherapy showed a trend towards improved 12-month PRS for distant recurrence (HR=0.32).
Conclusions:
- SNMM is characterized by high recurrence rates and poor prognosis.
- Primary neck treatment offers no significant reduction in recurrence.
- Immunotherapy may improve short-term survival for distant SNMM recurrence.
