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[Budesonide (Pulmicort) and exertion-induced asthma]
Schweizerische Medizinische Wochenschrift
|June 7, 1986
Summary
High-dose budesonide effectively reduced exercise-induced bronchoconstriction in adults with asthma. This study found budesonide mitigated bronchial hyperreactivity in responders, offering significant protection against asthma symptoms triggered by exercise.
Area of Science:
- Pulmonology
- Pharmacology
- Exercise Physiology
Background:
- Exercise-induced bronchoconstriction (EIB) is a common condition in asthma patients.
- Assessing EIB severity and treatment efficacy requires standardized testing protocols.
Purpose of the Study:
- To evaluate the efficacy of budesonide in preventing exercise-induced bronchoconstriction in adult asthmatics.
- To investigate the impact of a one-week high-dose budesonide regimen on bronchial hyperreactivity.
Main Methods:
- A randomized, crossover, double-blind trial involving 12 adult asthma patients.
- Exercise challenge using a treadmill, with spirometry (FEV1) measurements before and after exercise.
- Patients received either placebo or budesonide (2 x 800 micrograms daily) for one week each.
Main Results:
- A significant protective effect against EIB was observed with budesonide compared to placebo (8% additional protection).
- Budesonide treatment led to a significant reduction in the tendency for EIB.
- Patient recognition of budesonide inhalation suggests a noticeable effect, though non-responders were identified.
Conclusions:
- One week of high-dose budesonide can effectively reduce exercise-induced asthma in adults.
- Budesonide appears to mitigate bronchial hyperreactivity in individuals who respond to the medication.
- Further research is needed to understand non-responder variability.