Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nurses' Legal Responsibilities I01:27

Nurses' Legal Responsibilities I

784
In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:
784
Ethics in Research01:56

Ethics in Research

23.1K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
23.1K
Clinical Trials01:16

Clinical Trials

6.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.9K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

150
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
150
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.1K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.1K
Preclinical Development: Overview01:28

Preclinical Development: Overview

4.5K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardized Single-Session Cardiopulmonary Exercise Test for Measuring Peak Oxygen Uptake, Oxygen On/Off Kinetics, and Skeletal Muscle Oxygenation in ICU Survivors-ICU Combined Assessment of Cardiorespiratory Exercise (ICU-CARE) Study: Protocol for a Cross-Sectional Observational Study.

JMIR research protocols·2026
Same author

Apnea Testing for Brain Death/Death by Neurologic Criteria in Adults: A Prospective Multicenter Observational Study Assessing the Relationship Between Methodology, Safety, and Duration.

Critical care explorations·2026
Same author

Severity of Chronic Kidney Disease and Outcomes After Admission to the Intensive Care Unit.

JAMA network open·2026
Same author

Effects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.

Canadian journal of kidney health and disease·2026
Same author

Clinical Prediction Models for Prognostication After Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis.

Critical care medicine·2026
Same author

Mass cytometry reveals complex neutrophil heterogeneity in patients with severe sepsis.

Intensive care medicine experimental·2026

Related Experiment Video

Updated: Jul 28, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K

Informed consent practices in clinical research: present and future.

Natasha A Jawa1,2, J Gordon Boyd1,3,4,5, David M Maslove4,5

  • 1Centre for Neuroscience Studies, Faculty of Health Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada.

Postgraduate Medical Journal
|June 2, 2023
PubMed
Summary

Achieving true informed consent in clinical research is challenging, especially for vulnerable patients. This review explores methods to balance participant rights with recruitment needs for valid research.

Keywords:
ethicsintensive and critical caremedical ethicsneurological injuryneurology

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K
A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

8.3K

Related Experiment Videos

Last Updated: Jul 28, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K
A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

8.3K

Area of Science:

  • Clinical Research Ethics
  • Informed Consent Process
  • Participant Autonomy

Background:

  • Clinical research requires balancing participant recruitment with autonomy, centered on informed consent.
  • Current informed consent processes often fail to provide adequate information, impeding participant decision-making.
  • Vulnerable populations, including acutely ill or neurologically impaired patients, face heightened challenges in providing consent.

Approach:

  • This paper offers a comprehensive review of informed consent principles in research.
  • It examines the assessment of capacity to consent and considerations for patients unable to provide consent.
  • The review addresses substitute decision-making and consent under special circumstances.

Key Points:

  • Ensuring sufficient information is crucial for participants to make informed decisions.
  • Assessing capacity to consent is a critical component of the informed consent process.
  • Substitute decision-makers and special circumstances require careful consideration for ethical consent.
  • Strategies for balancing recruitment goals with robust informed consent are discussed.

Conclusions:

  • A thorough understanding of informed consent tenets is vital for ethical and effective clinical research.
  • Improving informed consent processes is essential for protecting participant autonomy and ensuring data validity.
  • Addressing the needs of vulnerable populations is paramount for inclusive and meaningful research participation.