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Decrease levels of bone morphogenetic protein 6 and noggin in chronic schizophrenia elderly.

Lin Sun¹, Qi Qiu¹, Chunxia Ban²

¹Department of Geriatric Psychiatry, Alzheimer's Disease and Related Disorders Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wanping Road, Xuhui Distinct, Shanghai, People's Republic of China.

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Summary

This summary is machine-generated.

Blood BMP6 and noggin levels are lower in elderly individuals with chronic schizophrenia (SCZ), particularly those with dementia. These markers correlate with cognitive function in SCZ patients.

Keywords:

APOE BMP6 Dementia Noggin Schizophrenia

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Area of Science:

Neuroscience
Biochemistry
Geriatrics

Background:

Chronic schizophrenia (SCZ) increases dementia risk in elderly individuals.
Bone morphogenetic protein 6 (BMP6) and noggin are implicated in dementia pathophysiology.
Investigating BMP6/noggin in SCZ and cognitive decline is crucial for understanding disease progression.

Purpose of the Study:

To examine the association between blood BMP6/noggin levels and cognitive function in elderly patients with chronic SCZ.
To compare BMP6/noggin levels between chronic SCZ patients and healthy controls.
To explore the influence of apolipoprotein E (APOE) genotype on BMP6 levels in SCZ.

Main Methods:

Blood BMP6, noggin, and cognitive function were assessed in 159 elderly SCZ patients and 171 healthy controls.
Apolipoprotein E (APOE) genotyping was performed on 157 participants.
Cognitive function was reassessed at 1-year follow-up in 208 participants.

Main Results:

Elderly SCZ patients exhibited lower blood BMP6 and noggin levels than controls, with the lowest levels in SCZ patients with dementia.
Combined BMP6 and noggin levels could differentiate SCZ patients from healthy controls.
APOE ε4 carriers with SCZ had reduced BMP6 levels compared to non-carriers.

Conclusions:

Blood BMP6 and noggin levels are significantly associated with cognitive performance in elderly individuals with chronic SCZ.
BMP6 and noggin may serve as potential biomarkers for cognitive impairment in chronic schizophrenia.
The findings highlight the role of BMP6/noggin in the neurobiological underpinnings of cognitive decline in SCZ.