Related Experiment Video
Updated: Jul 28, 2025
10:58
Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
Published on: February 22, 2015
13.0K
Diffuse Leptomeningeal Glioneuronal Tumour
Tom Saliba1,2, Grammatina Boitsios3
1Radiology, Hopital Universitaire Des Enfants Reine Fabiola, Brussels, BEL.
Cureus
|June 2, 2023
Summary
Diffuse leptomeningeal glioneuronal tumours (DL-GNT) are rare brain tumors. This case highlights typical MRI features of DL-GNT, emphasizing the need for better diagnostic criteria for this challenging condition.
Area of Science:
- Neuro-oncology
- Radiology
- Pediatric Oncology
Background:
- Diffuse leptomeningeal glioneuronal tumours (DL-GNT) are rare central nervous system neoplasms.
- Fewer than 100 cases have been reported since 2012, with an unknown incidence.
- Clinical presentations are often non-specific, encompassing both abdominal and neurological symptoms.
Observation:
- Radiological criteria for DL-GNT are not definitively established.
- Key observed features include nodular lesions, characteristic spread patterns, and leptomeningeal enhancement post-contrast.
- A 14-year-old male patient presented with an advanced DL-GNT case.
Findings:
- MRI scans of the patient revealed features consistent with the typical radiological presentation of DL-GNT.
- The case underscores the diagnostic challenges posed by the non-specific clinical and radiological findings of DL-GNT.
- Despite ongoing treatment, the patient experiences severe handicaps due to the disease's advanced nature.
Implications:
- This case emphasizes the importance of recognizing subtle radiological signs for early DL-GNT diagnosis.
- Further research is needed to establish definitive radiological criteria for DL-GNT.
- Improved diagnostic accuracy could lead to earlier intervention and potentially better patient outcomes for rare brain tumors.
