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Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
267

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache.

Xiu Yang1, DianXuan Guo2, Wei Huang3

  • 1Department of Neurology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, China.

Neural Plasticity
|June 2, 2023
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Summary

Episodic tension-type headache (ETTH) involves altered brain activity in the insula and posterior cingulate cortex. These findings offer insights into the neurobiology of ETTH, linking brain function to headache frequency.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Brain function

Background:

  • The neurobiological underpinnings of episodic tension-type headache (ETTH) are not well understood.
  • Investigating brain activity patterns can elucidate the mechanisms of ETTH.

Purpose of the Study:

  • To explore intrinsic brain functional activity alterations in patients with ETTH.
  • To identify specific brain regions associated with ETTH.

Main Methods:

  • Resting-state functional magnetic resonance imaging (rs-fMRI) was used.
  • 32 ETTH patients and 32 healthy controls (HCs) participated.
  • Fractional amplitude of low-frequency fluctuation (fALFF) analysis was performed.

Main Results:

  • ETTH patients showed increased fALFF in the right posterior and anterior insula compared to HCs.
  • Decreased fALFF was observed in the posterior cingulate cortex of ETTH patients.
  • fALFF in the right anterior insula correlated negatively with ETTH attack frequency.

Conclusions:

  • This study reveals distinct alterations in intrinsic brain activity in ETTH.
  • The insula and posterior cingulate cortex are key areas implicated in ETTH pathophysiology.
  • Findings contribute to understanding the neurobiological basis of ETTH.