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Updated: Jul 28, 2025

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
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Protective Effect of Ursodeoxycholic Acid on Liver Function in Pediatric Patients with Seizure Treated with

Khadije Rezaie Keikhaie1, Mohammad Hasan Mohammadi2, Khadijeh Saravani2,3

  • 1Department of Obstetrics and Gynecology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.

Maedica
|June 2, 2023
PubMed

Insights

Ursodeoxycholic acid may help protect liver function in children treated with phenobarbital for epilepsy. This study suggests it can improve liver enzymes in patients experiencing drug-induced liver injury.

Area of Science:

  • Pediatric Neurology
  • Hepatology
  • Pharmacology

Background:

  • Epilepsy is a prevalent neurological disorder requiring treatment, often with phenobarbital.
  • Phenobarbital treatment can lead to significant liver complications.
  • Identifying strategies to mitigate phenobarbital-induced hepatotoxicity is crucial.

Discussion:

  • Ursodeoxycholic acid demonstrated a beneficial effect on liver enzymes in pediatric patients.
  • The study suggests a protective role for ursodeoxycholic acid against phenobarbital-induced liver injury.
  • Further research is warranted to confirm these findings and establish optimal dosing.

Key Insights:

  • Ursodeoxycholic acid administration improved liver function markers in pediatric patients.
  • The intervention showed a relative effect in ameliorating liver injury caused by phenobarbital.
  • Liver enzyme levels were significantly improved in the ursodeoxycholic acid group compared to placebo.

Outlook:

  • Investigating the long-term efficacy and safety of ursodeoxycholic acid in this context.
  • Exploring the underlying mechanisms of ursodeoxycholic acid's hepatoprotective effects.
  • Evaluating ursodeoxycholic acid as an adjunct therapy for epilepsy patients on phenobarbital.

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