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Vitamin D and infertility.

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Vitamin D deficiency impacts reproductive health, affecting fertility and conditions like PCOS. Supplementation shows promise, improving pregnancy rates and alleviating symptoms in various gynecological disorders.

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Area of Science:

  • Reproductive Endocrinology
  • Gynecology
  • Endocrinology

Background:

  • Vitamin D deficiency is linked to reproductive health issues, including infertility, uterine fibroids, endometriosis, and polycystic ovarian syndrome (PCOS).
  • Understanding the role of vitamin D in reproductive physiology is crucial for addressing gynecological disorders and improving fertility outcomes.

Approach:

  • This review synthesizes recent publications on vitamin D supplementation and its effects on reproductive health parameters.
  • The analysis focuses on outcomes in infertile women, women with diminished ovarian reserve, uterine fibroids, endometriosis, PCOS, and infertile men.

Key Points:

  • Vitamin D supplementation in infertile women correlates with higher pregnancy rates and improved ovarian reserve.
  • Supplementation has shown benefits in reducing fibroid growth, alleviating endometriosis pain, and improving PCOS markers (e.g., testosterone, AMH, insulin).
  • In men, vitamin D levels positively correlate with sperm parameters, particularly motility.

Conclusions:

  • Vitamin D status is significantly relevant to reproductive physiology and success.
  • Maintaining adequate vitamin D levels may be a key factor in managing gynecological disorders and enhancing fertility.