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Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption

Athanasios A Tsekouras1,2, Panos Macheras3,4

  • 1Department of Chemistry, Laboratory of Physical Chemistry, National and Kapodistrian University of Athens, Athens, Greece.

European Journal of Drug Metabolism and Pharmacokinetics
|June 2, 2023
PubMed
Summary

Naloxone pharmacokinetics differ by administration route. Zero-order absorption models better describe intramuscular and intranasal naloxone delivery over finite times compared to traditional models.

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