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Updated: Jul 17, 2026
Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
Improved membrane stability of alginate-chitosan microcapsules by crosslinking with tannic acid
Li Chen1,2, Fang Jiang3, Haidan Xu3
1College of Pharmaceutical Science, Zhejiang University, Hangzhou, 310058, Zhejiang, People's Republic of China. chenl01@tzc.edu.cn.
Objective:
The insufficient stability of alginate-chitosan (ALG-CS) microcapsules in biorelevant media limits their applications in the biomedical field. Attempts were made to improve the membrane stability of ALG-CS microcapsules by noncovalent crosslinking with tannic acid.
Results:
The membrane stability of ALG-CS microcapsules in culture medium and serum was significantly improved by crosslinking with tannic acid. Moreover, the reason for the significant improvement in membrane stability had been demonstrated to be that the stability of chitosan-tannic acid (CS-TA) polyelectrolyte complexes was less affected by the competitive binding of those weak acid ions such as HCO3-. In addition, the optimal conditions for preparing alginate-chitosan-tannic acid (ALG-CS-TA) microcapsules were tannic acid concentration of 0.5% (w/v) and pH = 7.
Conclusion:
The study provides a novel approach for improving the stability of the ALG-CS microcapsules in biorelevant media to expand their scope of application in the biological field.
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