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Polyphenol-Based Nanosystems for Next-Generation Cancer Therapy: Multifunctionality, Design, and Challenges
Chenqian Feng1, Bo Chen1, Rangrang Fan2
1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Macromolecular Bioscience
|June 2, 2023
Summary
Polyphenols are emerging as multifunctional nanocarriers for cancer therapy, offering greener and more effective drug delivery. These compounds show promise in tumor cell ablation, overcoming multidrug resistance, and boosting immunotherapy.
Area of Science:
- Nanomedicine and Drug Delivery
- Cancer Therapeutics
- Precision Medicine
Background:
- Advancements in cancer treatment and precision medicine necessitate innovative drug delivery systems.
- There is a growing need for multifunctional nanomedicines beyond simple drug delivery.
- Polyphenols are being investigated as versatile, safe, and effective carriers in nanomedicine.
Purpose of the Study:
- To review recent progress in the design, synthesis, and application of polyphenol-based nanosystems for cancer therapy.
- To explore the potential of polyphenols as multifunctional carriers in cancer treatment modalities.
- To discuss the advantages and challenges of clinical translation for polyphenol delivery systems.
Main Methods:
- Comprehensive literature review of recent advances in polyphenol-based nanosystems for cancer therapy.
- Analysis of the design principles and synthesis strategies for these nanosystems.
- Evaluation of their therapeutic applications, including tumor cell ablation, overcoming multidrug resistance, and immunotherapy enhancement.
Main Results:
- Polyphenols exhibit intrinsic anticancer activities, demonstrating efficacy in tumor cell ablation and overcoming multidrug resistance (MDR).
- Polyphenol-based nanosystems show significant potential in enhancing immunotherapeutic efficacy.
- These versatile nanosystems can be designed for various cancer therapy modes.
Conclusions:
- Polyphenols serve as promising multifunctional building blocks and active ingredients for advanced nanomedicines.
- Polyphenol-based nanosystems offer a greener and potentially more effective approach to cancer therapy.
- Further optimization and validation are required for the clinical translation of these novel delivery systems.
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