Comparison of smear and imprint techniques for rapid diagnosis in neuro-oncology

The smear and imprint techniques were applied to brain tumor biopsy specimens and the resultant preparations compared for preservation of architecture and cell morphology. The imprint gave excellent detail of cell morphology and good preservation of architecture, especially in soft tumors. The method has enabled a rapid diagnosis to be made in 100 cases of intracranial lesions and is a valuable complement to smear and cryostat sections.