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Updated: Jul 28, 2025
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
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Advances in Enantiomer-Dependent Nanotherapeutics
Yuwen Wang1, Andy Tay1,2,3
1Department of Biomedical Engineering, National University of Singapore, Singapore 117583.
ACS Nano
|June 2, 2023
Summary
Chiral nanomaterials offer enhanced biomolecular interactions for improved nanotherapeutics. This review explores their synthesis, applications in cancer, and mechanisms for biological manipulation.
Area of Science:
- Nanomedicine
- Materials Science
- Biotechnology
Background:
- Biological systems exhibit inherent chirality and high enantiomeric selectivity.
- Nanomaterials, particularly nanoparticles, possess nanoscale properties (size, shape, surface charge) crucial for nanomedicine.
- Chirality manipulation in nanomaterials is gaining interest for enhanced biomolecular interactions and nanotherapeutics.
Purpose of the Study:
- To review the stereospecific interactions between chiral nanomaterials and biomolecules.
- To compare synthesis and characterization methods for chiral nanoparticles and nanoassemblies.
- To examine the applications of chiral nanotherapeutics in cancer, immunomodulation, and neurodegenerative diseases.
Main Methods:
- Literature review focusing on chiral nanostructures and their applications.
- Discussion of stereospecific interactions between chiral nanomaterials and biological targets.
- Comparison of synthesis and characterization techniques for chiral nanoparticles.
Main Results:
- Chiral nanostructures show promise beyond biosensing and diagnostics for nanomedicine.
- Applications in cancer therapy, immunomodulation, and neurodegenerative diseases are explored.
- Plausible mechanisms of chiral nanomaterial-cell interactions for biological manipulation are proposed.
Conclusions:
- Chiral nanomaterials represent a significant advancement in nanotherapeutics.
- Understanding chirality is key to unlocking new nanoscale modifications for improved biological outcomes.
- Further research into chiral nanotherapeutics holds potential for treating various diseases.
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