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Muscular involvement in long-term type 1 diabetes: Does it represent an underestimated complication?
Daniela Pollakova1, Claudio Tubili1, Ugo Di Folco1
1Diabetes Unit "S.Camillo - Forlanini" Hospital, Rome, Italy.
Type 1 diabetes (T1D) is linked to muscle damage, with a high prevalence of low muscle mass observed in long-term patients. Study suggests T1D duration impacts muscle health.
Area of Science:
- Endocrinology
- Metabolism
- Geriatrics
Background:
- Skeletal muscle damage is recognized in type 1 diabetes (T1D), yet diagnostic and treatment guidelines are lacking.
- Research on T1D and muscle health is limited, highlighting a gap in understanding and management.
Purpose of the Study:
- To determine the prevalence of sarcopenia in a long-term type 1 diabetes population.
- To investigate the influence of clinical factors on muscle mass and function in T1D patients.
Main Methods:
- Enrolled 39 T1D patients, measuring BMI, body composition (ALMI, FM), and muscle strength.
- Assessed the correlation between adherence to the Mediterranean diet and sarcopenia.
Main Results:
- Sarcopenia prevalence was 7.7% (12.5% in women, 4.35% in men). Low ALMI prevalence was 23.1%.
- Inverse correlations found between ALMI and diabetes duration/FM; positive correlations with BMI, physical activity, and strength.
- Muscle strength inversely correlated with diabetes duration and FM.
Conclusions:
- A high prevalence of low muscle mass was found, comparable to older general populations.
- T1D duration may play a significant role in the pathogenesis of muscle trophism and function.
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