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Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
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Potential applications of Fe
B N Swathi1, B R Radha Krushna1, M V Manjula2
1Prof. C.N.R. Rao Centre for Advanced Materials, Tumkur University, Tumkur 572 103, India.
Biomaterials Advances
|June 2, 2023
Summary
This study synthesized Fe3+-activated Sr9Al6O18 nanophosphors (SAO:Fe NPs) for enhanced latent fingerprint detection. These SAO:Fe NPs also demonstrate significant antioxidant and anti-thrombotic properties, suggesting dual applications in forensics and medicine.
Area of Science:
- Materials Science
- Forensic Science
- Biomedical Science
Background:
- Latent fingerprint (LFP) detection is crucial in forensics.
- Novel nanomaterials are needed to improve LFP visualization sensitivity and specificity.
- SAO:Fe NPs exhibit promising fluorescence properties.
Purpose of the Study:
- To synthesize Fe3+-activated Sr9Al6O18 nanophosphors (SAO:Fe NPs).
- To evaluate SAO:Fe NPs for latent fingerprint detection.
- To investigate the biomedical potential of SAO:Fe NPs in combating oxidative stress and thrombosis.
Main Methods:
- Solution combustion synthesis for SAO:Fe NPs.
- In-situ powder dusting and UV (254 nm) excitation for LFP visualization.
- Deep convolutional neural networks (YOLOv8x) for fingerprint feature analysis.
- DPPH scavenging assay and RBC oxidative stress models for antioxidant activity.
- ADP-induced platelet aggregation assay for anti-thrombotic potential.
Main Results:
- SAO:Fe NPs exhibit bright pale green fluorescence with high contrast and sensitivity for LFPs.
- Effective visualization of LFPs on diverse surfaces with no background interference.
- SAO:Fe NPs demonstrated significant antioxidant capacity and normalized oxidative stress markers.
- SAO:Fe NPs successfully inhibited platelet aggregation.
Conclusions:
- SAO:Fe NPs are effective for sensitive and specific latent fingerprint detection.
- SAO:Fe NPs possess significant antioxidant and anti-thrombotic activities.
- These nanophosphors show potential for dual applications in forensic science and advanced cardiology.
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