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Optimization and Deoptimization of Codons in SARS-CoV-2 and Related Implications for Vaccine Development

Xinkai Wu1, Ke-Jia Shan1, Fuwen Zan2

  • 1State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, 100871, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 2, 2023
PubMed
Summary

Codon usage in severe respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved to reduce protein expression, impacting virus fitness. Optimizing codons for spike mRNA vaccines (Omicron variants) enhanced expression, aiding vaccine development.

Keywords:
SARS-CoV-2codon optimizationcodon usage biasspike proteinsynonymous mutationsvaccine design

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