An integrated automatic lab-in-syringe sol-gel coated foam microextraction platform as a front-end to high...

The proof-of-concept of an integrated automatic foam microextraction lab-in-syringe (FME-LIS) platform coupled to high performance liquid chromatography is presented. Three different sol-gel coated foams were synthesized, characterized, and conveniently packed inside the glass barrel of the LIS syringe pump, as an alternative approach for sample preparation, preconcentration and separation. The proposed system efficiently combines the inherent benefits of lab-in-syringe technique, the good features of sol-gel sorbents, the versatile nature of foams/sponges, as well as the advantages of automatic systems. Bisphenol A (BPA) was used as model analyte, due to the increasing concern for the migration of this compound from household containers. The main parameters that affect the extraction performance of the system were optimized and the proposed method was validated. The limit of detection for BPA were 0.5 and 2.9 μg L-1, for a sample volume of 50 mL and 10 mL, respectively. The intra-day precision was <4.7% and the inter-day precision was <5.1% in all cases. The performance of the proposed methodology was evaluated for the migration studies of BPA using different food simulants, as well as for the analysis of drinking water. Good method applicability was observed based on the relative recovery studies (93-103%).