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Parthanatos type programmed cell death and septic patient mortality
Leonardo Lorente1, María M Martín2, Raquel Ortiz-López3
1Intensive Care Unit, Hospital Universitario de Canarias, Tenerife, Spain.
Medicina Intensiva
|June 2, 2023
Summary
Parthanatos, a cell death pathway, is linked to mortality in sepsis patients. Elevated serum apoptosis-inducing factor (AIF) levels indicate a higher risk of death in sepsis.
Area of Science:
- Cellular biology
- Immunology
- Critical care medicine
Background:
- Parthanatos is a programmed cell death pathway regulated by apoptosis-inducing factor (AIF).
- Limited data exist on parthanatos in septic patients.
- Sepsis is a life-threatening condition with high mortality rates.
Purpose of the Study:
- To investigate the association between parthanatos and mortality in patients with sepsis.
- To determine if serum AIF levels can predict mortality in septic patients.
Main Methods:
- An observational, prospective study was conducted in three Spanish ICUs in 2017.
- 195 patients diagnosed with sepsis (Sepsis-3 criteria) were included.
- Serum AIF concentrations were measured at sepsis diagnosis.
Main Results:
- Non-survivors (n=72) had significantly higher serum AIF levels, lactic acid, and APACHE-II scores compared to survivors (n=123).
- Logistic regression revealed that serum AIF levels >55.6 ng/mL were associated with a 3.29-fold increased mortality risk (p=0.002), independent of age, SOFA, and lactic acid.
- These findings highlight the prognostic value of AIF in sepsis.
Conclusions:
- Parthanatos is associated with mortality in septic patients.
- Serum AIF levels may serve as a predictive biomarker for mortality in sepsis.
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