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Cardiovascular issues in rheumatic diseases
Olena Zimba1,2,3, Armen Yuri Gasparyan4
1Department of Clinical Rheumatology and Immunology, University Hospital in Krakow, Macieja Jakubowskiego 2, 30-688, Krakow, Poland. zimbaolena@gmail.com.
Insights
Cardiovascular disease is a significant concern in rheumatic diseases. Systemic inflammation intensity strongly predicts vascular events, necessitating improved monitoring and prevention strategies for patients and specialists.
Area of Science:
- Rheumatology
- Cardiology
- Immunology
Background:
- Cardiovascular disease (CVD) is a leading cause of death in rheumatic diseases like rheumatoid arthritis and systemic lupus erythematosus.
- While inflammation is a known factor, accurate cardiovascular risk estimation in rheumatic diseases remains challenging, complicated by atherogenesis in conditions like fibromyalgia and osteoarthritis.
- Systemic inflammation intensity is linked to vascular events in inflammatory rheumatic diseases, highlighting the need for better risk assessment tools.
Purpose of the Study:
- To highlight the prevalence and significance of cardiovascular affections in rheumatic diseases.
- To address the critical issue of cardiovascular risk estimation in the context of rheumatic diseases.
- To advocate for enhanced cardiovascular monitoring and prevention strategies.
Main Methods:
- Review of existing literature on cardiovascular disease in rheumatic diseases.
- Analysis of cohort studies associating systemic inflammation with vascular events.
- Discussion of advanced visualization techniques for cardiovascular monitoring.
- Emphasis on patient and specialist education for risk factor management.
Main Results:
- Cardiovascular issues are common across all age groups in rheumatic diseases.
- Systemic inflammation intensity is a powerful predictor of vascular events in these patients.
- Current tools for predicting vascular events in inflammatory rheumatic diseases are not widely validated or reliable.
Conclusions:
- Tight control of systemic inflammation and modifiable cardiovascular risk factors is crucial for reducing vascular event risk.
- Improving knowledge and skills in cardiovascular monitoring and prevention for patients and specialists is essential.
- Empowering patients and primary care providers with knowledge is a promising strategy to mitigate cardiovascular risks in rheumatic diseases.
Abstract:
Cardiovascular disease is a major cause of morbidity and mortality in rheumatic diseases, particularly rheumatoid arthritis and systemic lupus erythematosus. Timely detection and monitoring of cardiovascular affections by advanced visualization techniques may improve outcomes across most rheumatic diseases. Although high-grade inflammation and (auto)immune pathways are well known for their negative effects on the heart and vasculature, cardiovascular risk estimation remains one of the unresolved critical issues in rheumatic diseases. The issue is complicated further in view of the latest reports on enhanced atherogenesis in the setting of fibromyalgia and osteoarthritis, where inflammation is seemingly not a major pathogenic factor. The intensity of systemic inflammation has been associated with major vascular events in some large cohort studies of inflammatory rheumatic diseases. Experts advocate for tight control of systemic inflammation and modifiable cardiovascular risk factors for reducing the overall risk of vascular events. Increasing patients' and specialists' knowledge and skills in cardiovascular monitoring and prevention is warranted to solve some of the cardiovascular issues in rheumatic diseases. Key Points • Cardiovascular issues are prevalent across all age groups of patients with rheumatic diseases. • Large cohort studies suggest that the intensity of systemic inflammation is a powerful predictor of vascular events in rheumatic diseases. • Reliable and widely tested tools for predicting vascular events in inflammatory rheumatic diseases are currently unavailable. • Empowering patients with rheumatic diseases and first-contact specialists with knowledge and skills to monitor and reduce cardiovascular risk factors' effects is a promising strategy.
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