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Updated: Jul 28, 2025

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Transient receptor potential ankyrin 1 (TRPA1) modulators: Recent update and future perspective

Zelin Hu1, Ya Zhang1, Wenhan Yu2

  • 1Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; College of Life Sciences, Sichuan University, Chengdu, 610064, China.

European Journal of Medicinal Chemistry
|June 3, 2023
PubMed
Summary

Developing novel TRPA1 modulators is crucial for treating pain, inflammation, and pruritus. This review focuses on structure-activity relationships of recent TRPA1 antagonists and agonists to inspire new drug development.

Keywords:
AgonistsAntagonistsIon channelTRPA1

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