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Updated: Jul 28, 2025
05:18
Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
Published on: July 12, 2024
365
Ambient black carbon reaches the kidneys
Leen Rasking1, Priyanka Koshy2, Eva Bongaerts1
1Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Environment International
|June 3, 2023
Summary
Black carbon (BC) particles accumulate in kidney tissue, potentially impairing function. Urinary biomarkers like KIM-1 and CysC may indicate kidney injury from air pollution exposure.
Area of Science:
- Environmental Health
- Nephrology
- Toxicology
Background:
- Ultrafine particles, including black carbon (BC), circulate systemically after inhalation.
- Kidneys are vulnerable to particle exposure due to their filtration role.
Purpose of the Study:
- To investigate BC particle presence in kidney tissue.
- To assess the association between BC exposure and kidney function biomarkers.
Main Methods:
- BC particles visualized in kidney biopsies using femtosecond-pulsed illumination.
- Urinary kidney injury molecule-1 (KIM-1) and cystatin c (CysC) measured via ELISA.
- Correlation and regression models used to link exposure and biomarkers.
Main Results:
- BC particles detected in all kidney biopsy samples, primarily in interstitium and tubules.
- Higher tissue BC load correlated with increased urinary KIM-1 levels.
- Proximity to major roads inversely associated with urinary CysC and KIM-1.
Conclusions:
- BC particle accumulation in kidneys offers a mechanism for air pollution's detrimental kidney effects.
- Urinary KIM-1 and CysC show promise as biomarkers for air pollution-induced kidney injury.
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