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Redox-responsive microemulsion: Fabrication and application to curcumin encapsulation.

Yongmin Zhang1, Meng Mu2, Yue Zhou3

  • 1The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical & Materials Engineering, Jiangnan University, Wuxi 214122, PR China; Key Laboratory of Green Cleaning Technology and Detergents of Zhejiang Province, Hangzhou 310056, PR China.

Journal of Colloid and Interface Science
|June 3, 2023
PubMed
Summary

Selenium-containing alcohols offer a novel approach to stimulus-responsive microemulsions. These redox-switchable systems enhance curcumin delivery, improving solubility, stability, antioxidant capacity, and skin penetration.

Keywords:
CurcuminMicroemulsionRedox-responsiveSelenium-containing

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Physical Chemistry

Background:

  • Stimulus-responsive microemulsions offer tunable properties for various applications.
  • Traditional responsive microemulsions often rely on stimuli-responsive surfactants.
  • A novel approach using redox-sensitive co-surfactants is explored for microemulsion stability control.

Purpose of the Study:

  • To design and synthesize a selenium-containing diol (PSeP) as a redox-responsive co-surfactant.
  • To investigate the redox-induced switchability of microemulsions incorporating PSeP.
  • To evaluate the potential of these microemulsions for encapsulating and delivering bioactive substances like curcumin.

Main Methods:

  • Synthesis and characterization of 3,3'-selenobis(propan-1-ol) (PSeP) using NMR and MS.
  • Formulation of microemulsions using PSeP, ethoxylated hydrogenated castor oil (HCO40), diethylene glycol monohexyl ether (DGME), 2-n-octyl-1-dodecanol (ODD), and water.
  • Assessment of microemulsion redox-responsiveness via phase diagrams, dynamic light scattering, and conductivity measurements.
  • Evaluation of curcumin encapsulation, solubility, stability, antioxidant activity, and skin penetrability.

Main Results:

  • Redox conversion of PSeP successfully switched microemulsion stability, altering the monophasic region.
  • Oxidation of PSeP (to PSeP-Ox) decreased emulsifying capacity, while reduction restored it.
  • PSeP-based microemulsions significantly enhanced curcumin's oil solubility (23-fold), stability, and antioxidant capacity (91.74% DPPH radical scavenging).
  • Improved skin penetrability of encapsulated curcumin was observed.

Conclusions:

  • Selenium-containing alcohols can act as effective redox-responsive co-surfactants in microemulsions.
  • These microemulsions provide a versatile nanoplatform for enhancing the delivery of bioactive compounds.
  • The findings open new avenues for developing smart drug delivery systems with tunable properties.