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Updated: Jul 28, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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A Systematic Review and Meta-Analysis on Effectiveness of Mineralocorticoid Receptor Antagonists in Reducing the Risk

Kaneez Fatima1, Dayab Asad2, Nafhat Shaikh3

  • 1Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

The American Journal of Cardiology
|June 3, 2023
PubMed

Insights

Mineralocorticoid receptor antagonists (MRAs) significantly lower the risk of developing atrial fibrillation (AF) by 23%. This benefit applies to both new-onset and recurrent AF cases, offering a protective effect for heart failure patients.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Mineralocorticoid receptor antagonists (MRAs) improve heart failure outcomes, especially in reduced ejection fraction.
  • The impact of MRAs on atrial fibrillation (AF) incidence and recurrence remains unclear.

Conclusions:

  • MRAs effectively reduce the overall risk of developing atrial fibrillation.
  • The protective effect of MRAs against AF is consistent for both initial onset and recurrence.

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