All lockdowns are not equal: Reducing epidemic impact through evolutionary computation

The impact of different lockdown strategies upon the total number of infections in an epidemic are evaluated for two models of infection: one in which the disease confers permanent immunity, and one in which it does not. The strategies are based upon the proportion of the population infected at a time in order to trigger lockdown, combined with the proportion of interactions removed during lockdown. The population, its interactions, and the relative strengths of those interactions are stored in a weighted contact network, from which edges are removed during lockdown. These edges are selected using an evolutionary algorithm (EA) designed to minimize total infections. Using the EA to select edges significantly reduces total infections in comparison to random selection. In fact, the EA results for the least strict conditions were similar or better to the random results for the most strict conditions, showing that a judicious choice of restrictions during lockdown has the greatest effect on reducing infections. Further, when using the most strict rules a smaller proportion of interactions can be removed to obtain similar or better results in comparison to removing a higher proportion of interactions for less strict rules.