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Updated: Jul 28, 2025
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Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
Published on: January 10, 2015
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Structural basis of envelope and phase intrinsic coupling modes in the cerebral cortex
Arnaud Messé1, Karl J Hollensteiner2, Céline Delettre3
1Institute of Computational Neuroscience, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg University, Martinistraße 52, Hamburg 20246, Germany.
Neuroimage
|June 3, 2023
Summary
Brain activity shows intrinsic coupling modes (ICMs) related to structural connectivity (SC). Both phase and envelope ICMs link to SC, with stronger correlations at higher frequencies, revealing key structure-function relationships.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Intrinsic coupling modes (ICMs) are observed in ongoing brain activity across scales.
- Two main types of ICMs exist: phase and envelope ICMs.
- The relationship between ICMs and underlying brain structure is not fully understood.
Purpose of the Study:
- To investigate the structure-function relationship between ICMs and structural connectivity (SC) in the ferret brain.
- To explore how computational models can predict ICMs based on SC.
- To analyze ICMs sensitive and insensitive to volume conduction effects.
Main Methods:
- Quantified ICMs from micro-ECoG recordings in ferrets.
- Obtained structural connectivity (SC) using diffusion MRI tractography.
- Employed large-scale computational models to predict ICMs.
Main Results:
- Both phase and envelope ICMs significantly correlate with SC, except for phase ICMs when removing zero-lag coupling.
- The correlation between SC and ICMs strengthens with increasing frequency.
- Computational models showed high parameter dependency; SC-based measures yielded the most consistent predictions.
Conclusions:
- Cortical functional coupling patterns, reflected in both phase and envelope ICMs, are related to structural connectivity.
- The degree of this relationship varies between ICM types.
- SC provides a basis for understanding large-scale functional brain dynamics.
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