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Updated: Jul 28, 2025

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
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Reconstructing cell lineage trees with genomic barcoding: approaches and applications.

Zizhang Li1, Wenjing Yang2, Peng Wu2

  • 1Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Department of Genetics and Biomedical Informatics, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

Journal of Genetics and Genomics = Yi Chuan Xue Bao
|June 3, 2023
PubMed
Summary

Researchers review methods for reconstructing cell lineage trees (CLTs), crucial for understanding organism development. DNA barcode-based approaches show promise for future biological discoveries due to their scalability and broad applicability.

Keywords:
BiotechnologyCell lineage treeComputational biologyDevelopmental regulation

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Area of Science:

  • Developmental Biology
  • Genomics
  • Cell Biology

Background:

  • Cell lineage trees (CLTs) organize cell division history and terminal cell functions in multicellular organisms.
  • Reconstructing CLTs is a fundamental goal in developmental biology and related scientific fields.

Purpose of the Study:

  • To review existing experimental approaches for reconstructing cell lineage trees (CLTs).
  • To summarize literature insights derived from CLT data.
  • To discuss future challenges and opportunities in CLT reconstruction and analysis.

Main Methods:

  • Categorization of CLT reconstruction methods into image-based and DNA barcode-based approaches.
  • Review of recent technological advancements, including editable genomic barcodes and single-cell high-throughput sequencing.
  • Literature synthesis based on biological insights from obtained CLTs.

Main Results:

  • Existing CLT reconstruction methods are broadly classified into image-based and DNA barcode-based techniques.
  • Technological advancements are driving new experimental methods for CLT reconstruction.
  • Genomic barcoding methods offer wide applicability and high scalability for CLT analysis.

Conclusions:

  • CLT reconstruction is advancing rapidly due to new technologies.
  • DNA barcode-based methods are particularly promising for future biological discoveries.
  • Further development of CLT data will present new challenges and opportunities for understanding developmental processes.