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AT1R gene rs389566 polymorphism contributes to MACCEs in hypertension patients
Jun-Yi Luo1,2, Guo-Li Du1,3, Yang-Min Hao3
1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, China.
Insights
The AT1R gene rs389566 TT genotype is linked to a higher risk of major adverse cardiovascular and cerebrovascular events (MACCEs) in hypertensive patients. This finding highlights the need for targeted prevention strategies in individuals with this genetic predisposition.
Area of Science:
- Cardiovascular Genetics
- Hypertension Research
- Pharmacogenomics
Background:
- Hypertension is a major risk factor for cardiovascular and cerebrovascular events.
- Genetic polymorphisms, such as in the Angiotensin II Receptor Type 1 (AT1R) gene, may influence individual susceptibility to these events.
- Understanding these associations can aid in personalized risk assessment and management.
Purpose of the Study:
- To investigate the association between AT1R gene polymorphisms and major adverse cardiovascular and cerebrovascular events (MACCEs).
- To assess this association in hypertensive patients in Xinjiang, with or without coronary artery disease (CAD).
Main Methods:
- Genotyping of AT1R gene polymorphisms using SNPscan™ typing assays in 374 CAD patients and 341 non-CAD hypertensive individuals.
- Follow-up assessments to record MACCEs.
- Kaplan-Meier curves and Cox survival analyses to determine associations.
Main Results:
- The AT1R gene rs389566 polymorphism was significantly associated with MACCEs.
- The TT genotype of rs389566 showed a higher probability of MACCEs (75.2%) compared to AA + AT genotypes (24.8%, P=0.033).
- Older age (OR=1.028) and the rs389566 TT genotype (OR=1.770) were identified as independent risk factors for MACCEs.
Conclusions:
- The AT1R gene rs389566 TT genotype may predispose hypertensive patients to MACCEs.
- Particular attention should be given to preventing MACCEs in hypertensive patients with CAD, especially the elderly with the rs389566 TT genotype.
- Lifestyle modifications, blood pressure control, and awareness of genetic risk factors are crucial for reducing MACCEs.
Objective:
To investigate the possible association between AT1R gene polymorphisms and major adverse cardiovascular and cerebrovascular events (MACCEs) in hypertension patients combined with or without coronary artery disease (CAD) in Xinjiang.
Methods:
374 CAD patients and 341 non-CAD individuals were enrolled as study participants and all of them have a hypertension diagnosis. AT1R gene polymorphisms were genotyped by SNPscan™ typing assays. During the follow-up in the clinic or by telephone interview, MACCEs were recorded. Kaplan-Meier curves and Cox survival analyses were used to explore the association between AT1R gene polymorphisms and the occurrence of MACCEs.
Results:
AT1R gene rs389566 was associated with MACCEs. The TT genotype of the AT1R gene rs389566 had a significantly higher probability of MACCEs than the AA + AT genotype (75.2% vs. 24.8%, P = 0.033). Older age (OR = 1.028, 95% CI: 1.009-1.0047, P = 0.003) and TT genotype of rs389566 (OR = 1.770, 95% CI: 1.148-2.729, P = 0.01) were risk factors of MACCEs. AT1R gene rs389566 TT genotype may be a predisposing factor for the occurrence of MACCEs in hypertensive patients.
Conclusion:
We should also pay more attention to the prevent of MACCEs in hypertension patients combined with CAD. Especially those elderly hypertensive patients carrying AT1R rs389566 TT genotype requires avoidance of unhealthy lifestyle, better management of blood pressure control and reduce the occurrence of MACCEs.
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