Related Experiment Video
Updated: Jul 28, 2025
06:14
Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
7.0K
Oxymatrine Loaded Cross-Linked PVA Nanofibrous Scaffold: Design and Characterization and Anticancer Properties
Salahuddin Ahmed1, Megan Keniry2, Narcedalia Anaya-Barbosa1
1Department of Mechanical Engineering, University of Texas Rio Grande Valley, Edinburg, TX, 78539, USA.
Macromolecular Bioscience
|June 4, 2023
Summary
Researchers developed biocompatible composite nanofibers using poly(vinyl alcohol) (PVA) and oxymatrine (OM). These OM-loaded PVA nanofibers effectively suppressed colorectal cancer cell proliferation, showing promise for drug delivery systems.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Research
Background:
- Composite nanofibers offer versatile platforms for biomedical applications.
- Oxymatrine (OM) is a natural compound with potential anticancer properties.
- Developing effective drug delivery systems for cancer therapy remains a critical challenge.
Purpose of the Study:
- To fabricate and characterize biocompatible composite nanofibers of poly(vinyl alcohol) (PVA), oxymatrine (OM), and citric acid (CA).
- To investigate the anticancer properties of these nanofibers against HCT116 colorectal cancer cells.
- To evaluate the potential of these nanofiber membranes as a drug delivery system.
Main Methods:
- Forcespinning technique for nanofiber fabrication.
- Microscopy, EDS, FTIR, DSC, and TGA for material characterization.
- In vitro anticancer assays using HCT116 colorectal cancer cells.
Main Results:
- Successfully fabricated PVA/OM/CA composite nanofibers with diameters ranging from 462 to 528 nm.
- Demonstrated thermal stability of the nanofiber mats at room temperature.
- Observed significant suppression of HCT116 colorectal cancer cell proliferation with high OM concentrations.
Conclusions:
- PVA/OM composite nanofibers are biocompatible and biodegradable.
- High concentrations of oxymatrine in PVA nanofibers effectively inhibit colorectal cancer cell growth.
- These nanofiber membranes show potential as a novel drug delivery system for cancer treatment.
