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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Pretherapy

Mei-Fang Cheng1,2, Yue Leon Guo2,3, Ruoh-Fang Yen1

  • 1Department of Nuclear Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

Korean Journal of Radiology
|June 4, 2023
PubMed
Summary
This summary is machine-generated.

Inflammation levels on 18F-fluorodeoxyglucose (FDG) PET/CT scans can predict relapse in immunoglobulin G4-related disease (IgG4-RD) patients. Whole-body total lesion glycolysis (WTLG) above 600 is a significant risk factor for disease recurrence.

Keywords:
IgG4-RDPET/CTRelapse-free survivalTherapy

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Area of Science:

  • Radiology
  • Nuclear Medicine
  • Immunology

Background:

  • Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition with a high relapse rate.
  • Standard induction steroid therapy is the first-line treatment for IgG4-RD.
  • Predicting relapse is crucial for optimizing patient management.

Purpose of the Study:

  • To determine if inflammation levels detected by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) can predict disease relapse in IgG4-RD patients.
  • To identify prognostic factors for relapse-free survival (RFS) in IgG4-RD patients undergoing steroid therapy.

Main Methods:

  • Prospective analysis of pretherapy FDG PET/CT scans from 48 IgG4-RD patients.
  • Patients received standard induction steroid therapy.
  • Multivariable Cox proportional hazards models were used to assess factors associated with RFS.

Main Results:

  • Relapse occurred in 81.3% of patients during a median follow-up of 1913 days.
  • Whole-body total lesion glycolysis (WTLG) > 600 on pretherapy FDG PET/CT was an independent risk factor for relapse.
  • Patients with WTLG > 600 had a significantly shorter median RFS (175 vs. 308 days).

Conclusions:

  • Pretherapy WTLG on FDG PET/CT is a significant predictor of disease relapse in IgG4-RD patients receiving steroid induction therapy.
  • WTLG is the sole significant factor associated with RFS in this patient cohort.