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The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
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Predicting the net administered activity in

Eric C Henry1, Benjamin Lopez1, Armeen Mahvash2

  • 1Department of Imaging Physics, UT MD Anderson Cancer Center, Houston, Texas, USA.

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|June 5, 2023
PubMed
Summary
This summary is machine-generated.

Accurate measurement of net administered activity (Aadmin) in 90Y-radioembolization is crucial. Novel SPECT/CT imaging reliably predicts Aadmin for both glass and resin microspheres, improving dosimetry and safety.

Keywords:
SIRTSPECT/CTYttrium-90quantificationradioembolization

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Area of Science:

  • Nuclear Medicine
  • Radiological Physics
  • Medical Imaging

Background:

  • Accurate determination of net administered activity (Aadmin) is vital for dosimetry and radiation safety in 90Y-radioembolization.
  • Current methods for measuring residual 90Y activity often have high uncertainty.
  • A clinically viable method for determining Aadmin across different 90Y microsphere devices is needed.

Purpose of the Study:

  • To develop and validate a novel method for determining Aadmin using quantitative SPECT/CT imaging.
  • To measure in vivo 90Y emission following 90Y-radioembolization with glass or resin microspheres.

Main Methods:

  • Analysis of attenuation-corrected 90Y-SPECT/CT data from 147 patients undergoing 90Y-radioembolization.
  • Development of univariate linear regression models to predict Aadmin based on SPECT counts, stratified by microsphere type (glass/resin) and SPECT volume (FOV/VOIliver).
  • Independent assessment of model performance using training and testing cohorts, with leave-one-out cross-validation.

Main Results:

  • Strong positive correlation (R2 > 0.98) between 90Y-SPECT counts and Aadmin for both microsphere types and analysis volumes.
  • High accuracy (>96.9%) and precision (<26.2%) in predicting Aadmin in testing cohorts for both glass and resin microspheres.
  • Significant differences in activity calibration observed between glass and resin microsphere devices, with resin yielding higher SPECT counts per equivalent activity.

Conclusions:

  • 90Y-SPECT/CT imaging provides a reliable method for predicting Aadmin after 90Y-radioembolization with accuracy >95% and precision <18%.
  • The method demonstrates equivalent performance for both glass and resin microspheres.
  • Activity calibration processes differ significantly between glass and resin 90Y microsphere devices.