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Longitudinal associations between stroke and psychosis: a population-based study.

Alvin Richards-Belle^1,2, Norman Poole³, David P J Osborn²

¹Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.

Psychological Medicine

|June 5, 2023

Summary

This summary is machine-generated.

Stroke independently predicts psychosis, and psychosis independently predicts stroke, over a 10-year period. This population-based study highlights a significant bidirectional association between these serious health conditions.

Keywords:

Delusions hallucinations neuropsychiatry psychotic disorder stroke

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Area of Science:

Neuroscience
Psychiatry
Epidemiology

Background:

The co-occurrence of stroke and psychosis presents a significant neuropsychiatric challenge.
Limited understanding exists regarding the longitudinal course of this comorbidity.

Purpose of the Study:

To estimate the longitudinal associations between stroke and psychosis over a 10-year period.
To investigate the bidirectional relationship between stroke and psychosis.

Main Methods:

A 10-year population-based study utilizing data from the English Longitudinal Study of Ageing.
Logistic and Cox proportional hazards regression, and Kaplan-Meier methods were employed.
Models were adjusted for demographic and health behavior covariates, with missing data imputed using random forest multiple imputation.

Main Results:

Participants with psychosis had a significantly higher probability of experiencing a first stroke (21.4%) compared to those without psychosis (8.3%).
Participants with stroke had a higher probability of reporting incident psychosis (2.3%) compared to those without stroke (0.9%).
Stroke was associated with a 3.57-fold increased hazard of psychosis, and psychosis with a 4.98-fold increased hazard of stroke, after full adjustment.

Conclusions:

Stroke is an independent predictor of psychosis.
Psychosis is an independent predictor of stroke.
These findings underscore the significant bidirectional relationship between stroke and psychosis.