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In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Updated: Jul 28, 2025

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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Diagnostic utility of

Kevin A Huynh1, James MacFarlane1, Christine Newman1

  • 1Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.

Clinical Endocrinology
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

11C-methionine PET/CT shows promise for diagnosing persistent primary hyperparathyroidism. This imaging technique aids in locating parathyroid adenomas, especially after prior unsuccessful surgeries or when other scans yield unclear results.

Keywords:
11C-methionine PET/CTmolecular/functional imagingparathyroid adenomaprimary hyperparathyroidism

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Area of Science:

  • Endocrinology
  • Nuclear Medicine
  • Surgical Oncology

Background:

  • Primary hyperparathyroidism (PHPT) is a common endocrine disorder, often caused by a single parathyroid adenoma.
  • Conventional imaging (ultrasound, 99mTc-sestamibi, 4D-CT) has limitations in diagnosing PHPT.
  • The utility of 11C-methionine PET/CT in PHPT management is not well-established.

Approach:

  • A retrospective single-center cohort study analyzed data from 45 patients who underwent 11C-methionine PET/CT between 2014 and 2022.
  • Imaging results were compared with histopathological and biochemical outcomes post-surgery to determine clinical utility.
  • The study focused on patients with persistent PHPT after surgery and those with failed localization by other modalities.

Key Points:

  • 11C-methionine PET/CT identified candidate lesions in 60% of patients with persistent PHPT post-surgery, with 50% confirmed histologically.
  • The modality correctly localized parathyroid adenomas in 75% of patients previously unlocalized by other imaging methods.
  • Overall sensitivity for parathyroid adenoma detection was 70%.

Conclusions:

  • 11C-methionine PET/CT demonstrates diagnostic value in complex PHPT cases.
  • It is particularly useful for patients with persistent disease after surgery or equivocal/negative prior imaging.
  • This technique can improve lesion localization, guiding more targeted surgical interventions.