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Cascade Synthesis of 5-Aminotetrazoles from Isonitriles and
Debashish Mishra1, Sauvik Kashyap1, Prodeep Phukan1
1Department of Chemistry, Gauhati University, Guwahati, Assam 781014, India.
Abstract:
A cascade protocol for the synthesis of aminotetrazoles have been developed by treating isonitriles, N,N-dibromoarylsulfonamides, and sodium azides in the presence of K2CO3. This metal-free process proceeds via an isolable carbodiimide intermediate at room temperature, which could further react with sodium azide and subsequently cyclizes intermolecularly to provide 5-aminotetrazoles within a short reaction time. The present protocol's remarkable achievements are the wide substrate scope, good to excellent yields, and good functional group tolerance.
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