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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: Jul 28, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

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Immunotherapy in leukaemia.

Xingmei Mu1, Chumao Chen1, Loujie Dong2

  • 1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Acta Biochimica Et Biophysica Sinica
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

Immunotherapy shows promise for acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL), but challenges remain. This review details progress, immune evasion mechanisms, and novel strategies for effective leukaemia treatment.

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Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Leukaemia encompasses diverse hematopoietic malignancies with complex classifications.
  • Significant advancements in immunotherapy research are noted for acute myeloid leukaemia (AML) and B-cell acute lymphoblastic leukaemia (B-ALL).

Approach:

  • This review summarizes fundamental immunotherapy approaches for leukaemia.
  • It focuses on research progress in AML and ALL immunotherapy development.
  • Mechanisms of tumour immune evasion in AML are examined, alongside therapeutic targets.

Key Points:

  • Despite progress, leukaemia immunotherapy effectiveness, particularly for AML, faces significant challenges.
  • Recent clinical trial data for bispecific antibodies, CAR-T-cell therapy, and checkpoint blockade are discussed.
  • Obstacles in identifying suitable treatment targets for AML are highlighted.

Conclusions:

  • Novel immunotherapy strategies and clinical outcomes for lymphocytic leukaemia are summarized.
  • The review provides insights into current and future directions for leukaemia immunotherapy.
  • Further research is needed to overcome existing obstacles and improve treatment efficacy.