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Emergence of Cutibacterium avidum with
Juri Koizumi1, Keisuke Nakase1, Hidemasa Nakaminami1
1Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
A novel macrolide-clindamycin resistance gene, erm(X), was found on the mobile genetic element Tn5432 in Cutibacterium avidum from an acne vulgaris patient. This finding is significant as erm(X) was previously unknown in this bacterial species.
Area of Science:
- Microbiology
- Genetics
- Dermatology
Background:
- Cutibacterium avidum is a skin bacterium.
- Antibiotic resistance is a growing concern in treating bacterial infections.
- The erm(X) gene confers resistance to macrolide and lincosamide antibiotics.
Purpose of the Study:
- To investigate the genetic basis of antibiotic resistance in a Cutibacterium avidum isolate.
- To identify mobile genetic elements carrying resistance genes in Cutibacterium avidum.
Main Methods:
- Bacterial isolation and identification.
- Antimicrobial susceptibility testing.
- Molecular analysis to identify resistance genes and mobile genetic elements.
Main Results:
- The Cutibacterium avidum isolate TP-CV302 harbored the erm(X) gene.
- The erm(X) gene was located on the mobile genetic element Tn5432.
- This is the first report of erm(X) in Cutibacterium avidum.
Conclusions:
- The mobile genetic element Tn5432 carrying erm(X) has been identified in Cutibacterium avidum.
- This discovery expands the known host range of this mobile genetic element and resistance gene.
- Understanding the spread of antibiotic resistance in skin bacteria like C. avidum is crucial for acne vulgaris treatment.
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