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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Evolutionary Relationships through Genome Comparisons02:54

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Genomic DNA in Eukaryotes00:58

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Genome Annotation and Assembly03:36

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Updated: Jul 28, 2025

Metagenomic Analysis of Silage
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Metagenomic Analysis of Silage

Published on: January 13, 2017

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Genomic analysis of

Mandy Man-Hsi Lin1, Michelle E Walker1, Vladimir Jiranek1,2

  • 1Department of Wine Science, School of Agriculture, Food & Wine, The University of Adelaide, Waite Campus, South Australia, 5064, Australia.

Microbial Genomics
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

Kazachstania yeast species impact wine aroma by altering acetate esters. Researchers sequenced their genomes, revealing gene differences related to ester production, aiding future studies on yeast evolution and fermentation.

Keywords:
Kazachstania aerobiaKazachstania servazziiPacBioester geneswhole genome sequencingwine aroma

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Area of Science:

  • Microbiology
  • Genomics
  • Oenology

Background:

  • Kazachstania aerobia and Kazachstania servazzii influence wine aroma through increased acetate ester production.
  • The genetic underpinnings of this phenomenon are largely unknown due to limited genomic data.

Purpose of the Study:

  • To sequence and annotate the genomes of K. aerobia and K. servazzii.
  • To compare these genomes with Saccharomyces cerevisiae to identify genetic variations related to ester biosynthesis.

Main Methods:

  • Utilized long-read PacBio sequencing for near-complete genome assembly.
  • Annotated the genomes and performed comparative genomic analysis.

Main Results:

  • Near-complete genomes for K. aerobia (12.5 Mb) and K. servazzii (12.3 Mb) were obtained.
  • Comparative analysis revealed minor differences between the two Kazachstania species but significant divergence in ester biosynthesis genes, including duplications and absences, compared to S. cerevisiae.

Conclusions:

  • The annotated genomes provide a crucial resource for understanding Kazachstania evolutionary biology and comparative genomics.
  • These genomic resources will facilitate future research into yeast metabolic processes, alcoholic fermentation, and the production of aromatic compounds.