Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

166
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
166
Empathy02:34

Empathy

9.6K
Some researchers suggest that altruism operates on empathy. Empathy is the capacity to understand another person’s perspective, to feel what he or she feels. An empathetic person makes an emotional connection with others and feels compelled to help (Batson, 1991). Empathy can be expressed in several ways, including cognitive, affective, and motor. 
9.6K
Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

85
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
85
Modeling in Therapy01:26

Modeling in Therapy

128
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
128
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

3.1K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.1K
Physiology of Emotion01:20

Physiology of Emotion

1.0K
The physiology of emotions is a multifaceted process involving the autonomic nervous system, brain structures, hormones, and neurotransmitters. This intricate interplay dictates how emotions manifest in the body and influence behavior.
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.

Translational psychiatry·2026
Same author

Association between Interictal Spike Rate and Seizure Frequency in a Large Epilepsy Cohort.

medRxiv : the preprint server for health sciences·2026
Same author

Genomic characterization of a pathogenic <i>Bacillus licheniformis</i> strain LSDY01: deciphering its genetic diversity and virulence-associated traits.

Frontiers in microbiology·2026
Same author

Bifidobacterium lactis XLTG11 Reduces Eczema and Infections in Infants: A Randomized Trial.

QJM : monthly journal of the Association of Physicians·2026
Same author

The association between motor coordination impairment and altered functional connectivity among autistic children.

Frontiers in pediatrics·2026
Same author

D-ribose-induced cytotoxicity in K562 cells: RBKS-dependent disruption of copper homeostasis and mitochondrial function.

Free radical biology & medicine·2026

Related Experiment Video

Updated: Jul 28, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.3K

Brain structure underlying the empathizing-systemizing difference in children with autism spectrum disorder.

Ning Pan1, Li-Zi Lin2, Xin Wang3,4

  • 1Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Road 2, Yuexiu District, Guangzhou, 510080, China.

World Journal of Pediatrics : WJP
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

Children with autism spectrum disorder (ASD) show a link between their empathizing-systemizing difference (D score) and brain structure. Amygdala volume and left lateral occipital cortex (LOC) gyrification may serve as biomarkers for this difference in ASD.

Keywords:
Autism spectrum disorderEmpathyStructural magnetic resonance imagingSystemizing

More Related Videos

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

9.0K
Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.6K

Related Experiment Videos

Last Updated: Jul 28, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.3K
Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

9.0K
Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.6K

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Autism Spectrum Disorder Research

Background:

  • Behavioral studies indicate a greater empathizing-systemizing difference (D score) in children with autism spectrum disorder (ASD) compared to typically developing children.
  • Existing research lacks investigation into the neuroanatomical underpinnings of this empathizing-systemizing difference in children with ASD.

Purpose of the Study:

  • To explore the neuroanatomical mechanisms associated with the empathizing-systemizing difference in children with ASD.
  • To investigate the relationship between brain morphometry and the D score in children with ASD and typically developing (TD) children.

Main Methods:

  • Structural magnetic resonance imaging (MRI) was used to quantify brain morphometry in 41 children with ASD and 39 TD children (aged 6–12 years).
  • Measures included global and regional brain volumes and surface-based cortical characteristics (cortical thickness, surface area, gyrification).
  • The empathizing-systemizing difference was assessed using the D score derived from the Chinese version of the Children's Empathy Quotient and Systemizing Quotient.

Main Results:

  • A significant negative association was found between the D score and amygdala gray matter volume in children with ASD.
  • In children with ASD, a negative association existed between D score and left lateral occipital cortex (LOC) gyrification.
  • A positive association was observed between D score and right fusiform gyrification in TD children, with significant interactions noted for amygdala volume and left LOC gyrification between groups.

Conclusions:

  • Neuroanatomical variations in amygdala volume and LOC gyrification may represent potential biomarkers for the empathizing-systemizing difference in children with ASD.
  • These brain structures did not show similar associations in typically developing children.
  • Replicability of these findings necessitates large-scale neuroimaging studies.