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Updated: Jul 28, 2025

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
Published on: February 12, 2011
Part 2: The Clinical Applications of Left Ventricular Myocardial Strain
Malcolm Anastasius1, Paaladinesh Thavendiranathan2, Annapoorna Kini1
1From the Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY.
Insights
Myocardial strain measures offer early detection of subtle left ventricular systolic dysfunction, outperforming traditional ejection fraction in certain heart conditions like valvular and cardiomyopathic diseases and COVID-19.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Echocardiography
Background:
- Cardiovascular disease and heart failure prevalence is rising.
- Left ventricular ejection fraction may not accurately reflect systolic function in all cardiac diseases.
- Reduced ejection fraction often indicates advanced, irreversible disease stages.
Purpose of the Study:
- To review emerging clinical applications of left ventricular global longitudinal strain (LV-GLS).
- To highlight LV-GLS utility in valvular heart disease, cardiomyopathies, and COVID-19.
- To emphasize LV-GLS for early identification of subtle left ventricular systolic dysfunction.
Main Methods:
- Review of current literature on left ventricular global longitudinal strain.
- Analysis of clinical applications in various cardiac pathologies.
- Focus on echocardiographic strain measurement techniques.
Main Results:
- Myocardial strain is a robust tool for early heart disease detection.
- LV-GLS identifies subtle systolic dysfunction missed by ejection fraction.
- Strain imaging shows promise in valvular diseases, cardiomyopathies, and COVID-19.
Conclusions:
- Left ventricular global longitudinal strain is a valuable metric for assessing myocardial function.
- Strain imaging offers earlier and more sensitive detection of cardiac dysfunction.
- This technique is crucial for managing patients with valvular, cardiomyopathic, and viral heart conditions.
Abstract:
There is an increasing prevalence of cardiovascular disease and heart failure. Indices of left ventricular (LV) systolic function such as LV ejection fraction used to identify those at risk of adverse cardiac events such as heart failure may not be truly representative of LV systolic function in certain cardiac diseases. Given that LV ejection fraction reduction may represent more advanced irreversible stages of disease, measures of myocardial strain have emerged as a feasible and robust instrument for the early identification of heart disease and subtle LV systolic dysfunction. The purpose of this review was to provide an overview of emerging clinical applications of LV global longitudinal strain in valvular and cardiomyopathic diseases and coronavirus disease 2019.
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