Related Experiment Video

Updated: Jul 27, 2025

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

989

Effects of curcumin on oral cancer at molecular level: A systematic review

Akhilesh Kumar Singh1, Naresh Kumar Sharma1, Nitesh Mishra1

  • 1Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

National Journal of Maxillofacial Surgery
|June 5, 2023
PubMed

Insights

Curcumin effectively inhibits oral cancer cell proliferation, migration, and invasion by impacting molecular pathways. Further clinical trials are needed to confirm these promising effects in patients.

Area of Science:

  • Molecular Biology
  • Oncology
  • Pharmacology

Background:

  • Oral cancer remains a significant global health challenge.
  • Curcumin, a compound from turmeric, shows potential anti-cancer properties.
  • Understanding curcumin's molecular effects on oral cancer is crucial for therapeutic development.

Purpose of the Study:

  • To systematically review the molecular effects of curcumin on oral cancer cells.
  • To summarize findings on curcumin's impact on proliferation, cell cycle, and metastasis.
  • To evaluate curcumin's potential as an anti-oral cancer agent.

Main Methods:

  • Systematic literature search of PubMed, ProQuest, Google Scholar, Science Direct, and Scopus (2006-2021).
  • Inclusion of in-vivo and in-vitro studies on curcumin's effects on oral cancer.
  • Analysis of 13 selected articles based on predefined criteria.

Main Results:

  • Curcumin significantly reduced oral cancer cell proliferation and growth (MTT assay).
  • Curcumin induced S phase cell cycle arrest and inhibited regulatory T cell (Treg) migration.
  • Curcumin reversed epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET).

Conclusions:

  • Curcumin demonstrates potent anti-proliferative, anti-migratory, anti-invasive, and anti-metastatic effects in oral cancer cell lines.
  • Curcumin induces apoptosis and modulates multiple signaling pathways.
  • Further clinical trials are warranted to validate curcumin's efficacy in oral cancer patients.
Keywords:
Apoptosiscurcuminmolecular leveloral squamous cell carcinoma

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