Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoreactivity vs autoimmunity: characteristics of autoantigen-specific CD4 T-cells in rheumatoid arthritis and health.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Systemic immune dysregulation in patients experiencing urogynaecological mesh failure.

BJUI compass·2026
Same author

SWIIM study protocol: a pre-post study evaluating the implementation of an established pediatric diabetes management program to improve glycemic outcomes for children and young people with type 1 diabetes.

Frontiers in endocrinology·2026
Same author

Relationship between rumination and symptoms of posttraumatic stress disorder - a cross-sectional network analysis.

Frontiers in psychiatry·2026
Same author

Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis.

Annals of the rheumatic diseases·2026
Same author

Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4<sup>+</sup> T cells.

Frontiers in immunology·2026
Same journal

Association between intestinal functional disorders and anal fistula: evidence from a retrospective case-control study.

PeerJ·2026
Same journal

Automated recognition of Meso-Cenozoic foraminifera from Senegalese sedimentary deposits using convolutional neural networks.

PeerJ·2026
Same journal

Genome-wide analysis of <i>HSP70</i> gene superfamily in kelp (<i>Saccharina japonica</i>): identification, characterization, and heat stress-responsive expression profiles.

PeerJ·2026
Same journal

Morphological and molecular evidence of the Antarctic sleeper shark <i>Somniosus antarcticus</i> (Somniosidae) in northern Chile.

PeerJ·2026
Same journal

Stroboscopic balance training enhances dynamic stability and postural control in collegiate badminton players: a randomized controlled trial.

PeerJ·2026
Same journal

Frequent exposure to biologics is associated with small intestinal bacterial overgrowth in patients with Crohn's disease: a retrospective case-control study.

PeerJ·2026
See all related articles

Related Experiment Video

Updated: Jul 27, 2025

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
11:34

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

Published on: April 11, 2025

354

Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?

Ayesha Sahar1, Ioana Nicorescu2, Gabrielle Barran2

  • 1School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom.

Peerj
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

The Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) reporting framework has had limited adoption (14%) in the tolerogenic dendritic cells (tolDCs) field. While it slightly improves metadata, wider use is needed for standardized reporting in cell therapy research.

Keywords:
Cell therapyFAIR dataMetadata sharingMinimum information modelOpen data sharingReporting guidelinesStandardised data reportingTolerogenic dendritic cell

More Related Videos

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.8K
Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes
06:09

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

23.2K

Related Experiment Videos

Last Updated: Jul 27, 2025

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
11:34

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

Published on: April 11, 2025

354
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.8K
Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes
06:09

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

23.2K

Area of Science:

  • Immunology
  • Cell Therapy
  • Biotechnology

Background:

  • Minimum information models standardize scientific reporting for reproducibility and comparison.
  • Tolerogenic antigen-presenting cells (tolAPCs), including tolerogenic dendritic cells (tolDCs), are crucial for immune tolerance and cell therapies.
  • Existing protocols for generating tolDCs are highly variable, necessitating standardized reporting.

Purpose of the Study:

  • To evaluate the impact and adoption of the Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) framework.
  • To assess the extent to which MITAP has influenced reporting standards in the tolDC research field.

Main Methods:

  • Literature review of a subset of publications on tolDCs.
  • Analysis of the usage of the MITAP framework in the selected literature.
  • Quantification of metadata availability in papers using MITAP versus those not using it.

Main Results:

  • MITAP was utilized in only 14% of the examined tolDC literature.
  • Papers employing MITAP showed a marginal increase in available metadata compared to non-MITAP papers.
  • The adoption of standardized reporting through MITAP has been limited.

Conclusions:

  • MITAP has achieved partial success in the tolDC field.
  • Significant efforts are required to increase the adoption of MITAP and achieve widespread standardized reporting.
  • Further community engagement and integration are necessary for MITAP's broader impact on cell therapy research.