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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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Aging brain shows joint declines in brain within-network connectivity and between-network connectivity: a

Yuhui Du1,2, Yating Guo1, Vince D Calhoun2

  • 1School of Computer and Information Technology, Shanxi University, Taiyuan, China.

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Summary

This study reveals diverse whole-brain aging effects, showing altered functional network connectivity within and between brain networks. Findings highlight synergistic and paradoxical changes, offering new insights into non-pathological brain aging.

Keywords:
NeuroMarkbrain functional networkfunctional network connectivityjoint changesnormal brain aging

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Area of Science:

  • Neuroimaging
  • Brain Aging
  • Functional Connectivity

Background:

  • Aging impacts specific brain networks and reduces functional connectivity.
  • Previous studies have not comprehensively examined whole-brain aging effects on both within-network and between-network connectivity.
  • Understanding these changes is crucial for characterizing non-pathological brain aging.

Purpose of the Study:

  • To investigate the effects of aging on whole-brain functional networks (FNs) and functional network connectivity (FNC).
  • To identify aging-related changes in both within-network and between-network connectivity.
  • To explore synergistic and paradoxical changes between FNs and FNCs.

Main Methods:

  • Utilized a large UK Biobank dataset (6300 healthy adults, 49-73 years).
  • Employed priori-driven independent component analysis (ICA) via NeuroMark to extract FNs and FNCs.
  • Applied a two-level statistical analysis and a combined approach to analyze aging effects and joint changes.

Main Results:

  • Aging altered both within-network and between-network connectivity.
  • Reduced FNCs were observed within and between domains (visual, cognitive control, cerebellum).
  • Enhanced FNCs primarily occurred between domains (default mode, cognitive control); increased within-network connectivity was seen in sensorimotor networks, while decreased connectivity involved the default mode network.

Conclusions:

  • Aging exhibits diverse effects across the whole brain's functional networks.
  • The study provides novel insights into the complex interplay of FNs and FNCs during non-pathological aging.
  • Findings emphasize the heterogeneity of brain aging processes.