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Related Experiment Videos

[Pathomorphological changes in experimental Erysipelothrix infection in lambs].

A K Angelov, I Borisov, I Nikiforov

    Veterinarno-Meditsinski Nauki
    |January 1, 1986
    PubMed
    Summary

    Erysipelothrix rhusiopathiae infection in lambs causes polyarthritis and organ lesions. Early stages show neutrophil infiltration, while later stages reveal reticulohistiocytic proliferation and glomerulonephritis.

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    Area of Science:

    • Veterinary Pathology
    • Microbiology
    • Animal Disease Models

    Context:

    • Investigating the pathological effects of Erysipelothrix rhusiopathiae in a lamb model.
    • Understanding the progression of lesions following intravenous inoculation.

    Purpose:

    • To document the morphologic changes in lambs infected with Erysipelothrix rhusiopathiae.
    • To characterize the temporal development of lesions in experimentally infected lambs.

    Summary:

    • Lambs inoculated with Erysipelothrix rhusiopathiae developed polyarthritis.
    • Early lesions (days 2-7) included neutrophil infiltration in parenchymal organs, liver necrosis, and spleen, lung, and brain hyperemia/edema/hemorrhage.
    • Later lesions (after day 7) involved reticulohistiocytic proliferation in the liver and heart, intracapillary glomerulonephritis, thromboendocarditis, and persistent polyarthritis.

    Impact:

    • Provides detailed pathological insights into Erysipelothrix rhusiopathiae-induced disease in lambs.
    • Contributes to the understanding of bacterial polyarthritis pathogenesis.
    • Informs diagnostic strategies and potential therapeutic targets for erysipelothrix infections in livestock.

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