Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effects of Chemicals: Overview01:27

Effects of Chemicals: Overview

1.3K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.3K
Effects of feedback01:24

Effects of feedback

613
Feedback in control systems plays a critical role in shaping various operational parameters, extending beyond simple error reduction to influence stability, bandwidth, gain, impedance, and sensitivity. Understanding these effects requires examining a basic feedback system characterized by defined input, output, error, and feedback signals.
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...
613
Leveling Effect01:29

Leveling Effect

844
In acid-base chemistry, the leveling effect refers to the limitation imposed by the solvent on the strength of acids and bases in solution. When a base stronger than the solvent's conjugate base is used, it deprotonates the solvent until the base is entirely consumed, making it ineffective against weaker acids. Conversely, an acid stronger than the solvent's conjugate acid protonates the solvent until the acid is depleted, rendering it ineffective against weaker bases. Essentially, the...
844
Law of Effect01:06

Law of Effect

1.5K
B.F. Skinner, a prominent figure in behavioral psychology, introduced operant conditioning by emphasizing the role of consequences in shaping behavior. This theory builds upon the law of effect proposed by Edward Thorndike, which posits that behaviors followed by satisfying outcomes are likely to be repeated. In contrast, those followed by unsatisfying outcomes are less likely to recur.
Edward Thorndike's foundational work involved studying learning in animals, particularly using puzzle...
1.5K
Statistical Significance01:50

Statistical Significance

20.2K
Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
20.2K
The Placebo Effect01:54

The Placebo Effect

6.2K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Honeysuckle as a Bio-Enhancer in <i>Monascus purpureus</i> Fermentation: Synergistic Improvement of Monacolin K Yield and Flavor Complexity.

Foods (Basel, Switzerland)·2026
Same author

Improvement of Monacolin K and Pigment Production in <i>Monascus</i> by 5-Azacytidine.

Journal of fungi (Basel, Switzerland)·2024
Same author

Identification of characteristic volatiles and metabolomic pathways during the fermentation of red grapefruit by Monascus purpureus using HS-SPME-GC-MS and metabolomics.

Food chemistry·2024
Same author

Functional Verification of Transcription Factor comp54181_c0 in Monascus purpureus.

Journal of basic microbiology·2024
Same author

Mutation Breeding of <i>Monascus</i> to Produce a High Yield of Orange Pigment and Low Citrinin Content Using the ARTP Method.

Journal of fungi (Basel, Switzerland)·2024
Same author

Occurrence, Risk Implications, Prevention and Control of CIT in <i>Monascus</i> Cheese: A Review.

Journal of agricultural and food chemistry·2024

Related Experiment Video

Updated: Jul 27, 2025

A Task for Assessing the Impact of a Partner on the Speed and Accuracy of Motor Performance in Rats
06:17

A Task for Assessing the Impact of a Partner on the Speed and Accuracy of Motor Performance in Rats

Published on: October 17, 2019

5.0K

Effect of

Arzugul Ablimit1, Yang Yu1, Xin Jin1

  • 1Department of Food Science and Engineering, Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China.

Experimental and Therapeutic Medicine
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

Momordica charantia polysaccharides (MCPs) show potential in boosting immune function in immunosuppressed mice. Studies indicate MCPs improve organ indices, enhance macrophage activity, and increase lymphocyte proliferation and key cytokine levels.

Keywords:
Momordica charantia polysaccharidecytokineimmunomodulationlymphocytemRNA

More Related Videos

Experimental Paradigm for Measuring the Effect of Induced Emotion on Grammar Learning
05:33

Experimental Paradigm for Measuring the Effect of Induced Emotion on Grammar Learning

Published on: January 29, 2020

6.1K
The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
08:24

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

Published on: August 25, 2023

776

Related Experiment Videos

Last Updated: Jul 27, 2025

A Task for Assessing the Impact of a Partner on the Speed and Accuracy of Motor Performance in Rats
06:17

A Task for Assessing the Impact of a Partner on the Speed and Accuracy of Motor Performance in Rats

Published on: October 17, 2019

5.0K
Experimental Paradigm for Measuring the Effect of Induced Emotion on Grammar Learning
05:33

Experimental Paradigm for Measuring the Effect of Induced Emotion on Grammar Learning

Published on: January 29, 2020

6.1K
The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
08:24

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

Published on: August 25, 2023

776

Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products

Background:

  • Momordica charantia polysaccharides (MCPs) are known for medicinal properties, but their immunomodulatory effects are underexplored.
  • Understanding MCPs' impact on immune function is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To investigate the immunomodulatory effects of Momordica charantia polysaccharide (MCP) on lymphocytes in immunosuppressed mice.
  • To evaluate MCP's potential to restore immune function following cyclophosphamide-induced immunosuppression.

Main Methods:

  • Male BALB/c mice were divided into six groups: normal, immunosuppressed model, positive control (levamisole), and three MCP dose groups (100, 200, 300 mg/kg).
  • Immunosuppression was induced using cyclophosphamide. Treatments were administered orally for 21 days.
  • Key immune parameters assessed included thymus and spleen indices, lymphocyte proliferation, peritoneal macrophage phagocytosis, and cytokine (IFN-γ, IL-6, IL-12) levels.

Main Results:

  • MCP treatment significantly increased thymus and spleen indices in immunosuppressed mice compared to the model group.
  • MCP enhanced the inhibitory rate of delayed allergic reactions and improved peritoneal macrophage phagocytic activity.
  • MCP significantly upregulated lymphocyte proliferation, secretion, and mRNA expression of IFN-γ, IL-6, and IL-12.

Conclusions:

  • Momordica charantia polysaccharides (MCPs) demonstrate significant immunomodulatory effects in immunosuppressed mice.
  • MCPs enhance key immune responses, including organ indices, cellular immunity, and cytokine production.
  • MCPs hold promise as a natural compound for improving immune function in compromised individuals.